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• Activity deltas table
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Motif ID: FOS_FOS{B,L1}_JUN{B,D}.p2

Z-value: 2.405

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr17_-_39216343	33.076	NM_001165252	LOC730755	keratin associated protein 2-4-like
chr1_-_95007139	31.361	NM_001178096 NM_001993	F3	coagulation factor III (thromboplastin, tissue factor)
chr1_-_153013593	30.479	NM_006945	SPRR2D	small proline-rich protein 2D
chr19_-_36019194	28.329	NM_001166034 NM_001166035 NM_198538	SBSN	suprabasin
chr5_+_147582338	27.728	NM_001195290 NM_205841	SPINK6	serine peptidase inhibitor, Kazal type 6
chr1_-_153029987	27.029	NM_005988	SPRR2A	small proline-rich protein 2A
chr18_+_61554938	27.015	NM_001143818 NM_002575	SERPINB2	serpin peptidase inhibitor, clade B (ovalbumin), member 2
chr16_-_2908105	23.099	NM_022119	PRSS22	protease, serine, 22
chr7_+_28725597	22.877	NM_001011666	CREB5	cAMP responsive element binding protein 5
chr7_+_73245192	22.708	NM_001305	CLDN4	claudin 4
chr1_+_152486977	20.799	NM_019060	CRCT1	cysteine-rich C-terminal 1
chr12_-_58159386	20.791		CYP27B1	cytochrome P450, family 27, subfamily B, polypeptide 1
chr11_-_67141647	19.996	NM_001166212	CLCF1	cardiotrophin-like cytokine factor 1
chr11_-_65667858	17.739		FOSL1	FOS-like antigen 1
chr19_-_51523272	17.268	NM_002776 NM_001077500	KLK10	kallikrein-related peptidase 10
chr1_-_45272956	17.072	NM_001013632	TCTEX1D4	Tctex1 domain containing 4
chr11_-_65667809	17.054		FOSL1	FOS-like antigen 1
chr1_-_153067000	16.994	NM_001024209	SPRR2E	small proline-rich protein 2E
chr11_-_65667860	16.619	NM_005438	FOSL1	FOS-like antigen 1
chr19_-_35981345	16.225	NM_001244847 NM_207392	KRTDAP	keratinocyte differentiation-associated protein
chr1_+_153003677	15.476	NM_003125	SPRR1B	small proline-rich protein 1B
chr17_+_74381186	15.252	NM_001142602	SPHK1	sphingosine kinase 1
chr9_+_5510544	15.094	NM_025239	PDCD1LG2	programmed cell death 1 ligand 2
chr19_-_44174497	14.864	NM_001005376 NM_001005377 NM_002659	PLAUR	plasminogen activator, urokinase receptor
chr19_-_39264144	14.815	NM_002307	LGALS7 LGALS7B	lectin, galactoside-binding, soluble, 7 lectin, galactoside-binding, soluble, 7B
chr1_+_35225341	14.801	NM_153212	GJB4	gap junction protein, beta 4, 30.3kDa
chr17_+_74381419	14.445		SPHK1	sphingosine kinase 1
chr17_+_74380943	14.386		SPHK1	sphingosine kinase 1
chr22_-_30642683	13.815	NM_002309	LIF	leukemia inhibitory factor (cholinergic differentiation factor)
chr17_-_3461030	13.615		TRPV3	transient receptor potential cation channel, subfamily V, member 3
chr3_+_11178778	12.992	NM_001098213	HRH1	histamine receptor H1
chr7_+_28448970	12.571		LOC401317	uncharacterized LOC401317
chr19_-_40931880	12.496	NM_013376	SERTAD1	SERTA domain containing 1
chr1_+_247579457	12.193	NM_001079821 NM_001127461	NLRP3	NLR family, pyrin domain containing 3
chr8_+_126442557	11.637	NM_025195	TRIB1	tribbles homolog 1 (Drosophila)
chr4_+_74606222	11.601	NM_000584	IL8	interleukin 8
chr4_+_84457390	11.528	NM_032717	AGPAT9	1-acylglycerol-3-phosphate O-acyltransferase 9
chr5_+_52776479	11.515		FST	follistatin
chr2_-_65593763	11.502		SPRED2	sprouty-related, EVH1 domain containing 2
chr19_-_44174271	11.421		PLAUR	plasminogen activator, urokinase receptor
chr17_+_21191347	11.335	NM_002756	MAP2K3	mitogen-activated protein kinase kinase 3
chr2_-_65593866	11.089	NM_001128210	SPRED2	sprouty-related, EVH1 domain containing 2
chr1_+_152956563	11.069	NM_001199828 NM_005987	SPRR1A	small proline-rich protein 1A
chr11_-_2950593	10.937	NM_003311	PHLDA2	pleckstrin homology-like domain, family A, member 2
chr19_-_51472816	10.487	NM_002774	KLK6	kallikrein-related peptidase 6
chr1_-_179112178	10.277	NM_001136000 NM_001168239 NM_005158	ABL2	v-abl Abelson murine leukemia viral oncogene homolog 2
chr3_-_149095413	9.918		TM4SF1	transmembrane 4 L six family member 1
chr7_+_48128225	9.676	NM_181597	UPP1	uridine phosphorylase 1
chr6_-_159239198	9.547		EZR	ezrin
chr19_+_7953380	9.526	NM_025061	LRRC8E	leucine rich repeat containing 8 family, member E
chr20_-_1309782	9.476		SDCBP2	syndecan binding protein (syntenin) 2
chr3_-_149095517	9.469	NM_014220	TM4SF1	transmembrane 4 L six family member 1
chr6_-_159239269	9.460	NM_003379	EZR	ezrin
chrX_-_154563735	9.449	NM_001289	CLIC2	chloride intracellular channel 2
chr16_+_4430878	9.409		VASN	vasorin
chr1_+_183155173	9.355	NM_005562 NM_018891	LAMC2	laminin, gamma 2
chr3_-_149095458	9.307		TM4SF1	transmembrane 4 L six family member 1
chr4_+_84457256	9.301		AGPAT9	1-acylglycerol-3-phosphate O-acyltransferase 9
chr17_-_39768939	9.210	NM_005557	KRT16	keratin 16
chr5_-_134914447	9.100		CXCL14	chemokine (C-X-C motif) ligand 14
chr20_+_44637539	9.099	NM_004994	MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr1_-_153123426	8.784	NM_001014291	SPRR2G	small proline-rich protein 2G
chr11_+_66790189	8.756	NM_001177880	SYT12	synaptotagmin XII
chr6_+_47666288	8.720	NM_153838	GPR115	G protein-coupled receptor 115
chr3_-_149095333	8.580		TM4SF1	transmembrane 4 L six family member 1
chr6_-_159239254	8.568		EZR	ezrin
chr8_-_103666018	8.552	NM_001032282	KLF10	Kruppel-like factor 10
chr6_+_83072922	8.497	NM_006670	TPBG	trophoblast glycoprotein
chr8_-_82395401	8.309	NM_001442	FABP4	fatty acid binding protein 4, adipocyte
chr11_-_102668822	8.277		MMP1	matrix metallopeptidase 1 (interstitial collagenase)
chr1_+_152881022	8.269	NM_005547	IVL	involucrin
chr8_-_143695812	8.254	NM_015193	ARC	activity-regulated cytoskeleton-associated protein
chr12_+_13349716	8.152		EMP1	epithelial membrane protein 1
chr1_-_207205996	8.093	NM_001083924 NM_023938	C1orf116	chromosome 1 open reading frame 116
chr8_-_143851223	8.037	NM_177458	LYNX1	Ly6/neurotoxin 1
chr11_+_12308446	7.985	NM_032867	MICALCL	MICAL C-terminal like
chr5_-_134914968	7.954	NM_004887	CXCL14	chemokine (C-X-C motif) ligand 14
chr17_-_8021806	7.920	NM_021628	ALOXE3	arachidonate lipoxygenase 3
chr18_+_61637262	7.918	NM_001031848 NM_002640 NM_198833	SERPINB8	serpin peptidase inhibitor, clade B (ovalbumin), member 8
chr1_+_183155361	7.763		LAMC2	laminin, gamma 2
chr12_+_56075329	7.696	NM_152637	METTL7B	methyltransferase like 7B
chr5_+_52776408	7.665		FST	follistatin
chr13_-_36429798	7.658	NM_001195415 NM_001195416 NM_001195430	DCLK1	doublecortin-like kinase 1
chr12_+_13349720	7.569		EMP1	epithelial membrane protein 1
chr1_-_156675237	7.540	NM_001878 NM_001199723	CRABP2	cellular retinoic acid binding protein 2
chr19_+_39279849	7.463	NM_001042507	LGALS7B	lectin, galactoside-binding, soluble, 7B
chr21_-_36421195	7.407		RUNX1	runt-related transcription factor 1
chr17_-_18907988	7.400	NM_001039999	FAM83G	family with sequence similarity 83, member G
chr17_-_8022134	7.363	NM_001165960	ALOXE3	arachidonate lipoxygenase 3
chr1_-_36817157	7.339
chr12_+_13349601	7.312	NM_001423	EMP1	epithelial membrane protein 1
chr3_-_48601200	7.311	NM_033199	UCN2	urocortin 2
chr1_-_120311466	7.286	NM_001166107 NM_005518	HMGCS2	3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
chr21_-_36421461	7.286		RUNX1	runt-related transcription factor 1
chr21_-_36421578	7.243		RUNX1	runt-related transcription factor 1
chr17_-_3461288	7.230	NM_145068	TRPV3	transient receptor potential cation channel, subfamily V, member 3
chrX_+_115567746	7.228	NM_007231	SLC6A14	solute carrier family 6 (amino acid transporter), member 14
chrX_-_19688991	7.212	NM_001184960	SH3KBP1	SH3-domain kinase binding protein 1
chr12_+_56075418	7.203		METTL7B	methyltransferase like 7B
chr5_+_176875325	7.202	NM_001174102	PRR7	proline rich 7 (synaptic)
chr1_-_201346783	7.194		TNNT2	troponin T type 2 (cardiac)
chr1_+_183155393	7.178		LAMC2	laminin, gamma 2
chr11_-_118134956	7.159		MPZL2	myelin protein zero-like 2
chr1_+_24645914	7.084	NM_001195010	GRHL3	grainyhead-like 3 (Drosophila)
chr1_+_152974222	7.082	NM_001097589 NM_005416	SPRR3	small proline-rich protein 3
chr1_+_24645811	7.070	NM_198173 NM_198174	GRHL3	grainyhead-like 3 (Drosophila)
chr1_+_27189628	7.053	NM_006142	SFN	stratifin
chr5_+_68788118	6.993	NM_002538	OCLN	occludin
chr7_+_1126442	6.895	NM_001039966 NM_001505	GPER	G protein-coupled estrogen receptor 1
chr1_+_44398991	6.769	NM_001136215 NM_057090 NM_057091	ARTN	artemin
chr5_+_52776263	6.734	NM_006350 NM_013409	FST	follistatin
chr7_+_1577118	6.615		MAFK	v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr12_-_8815370	6.595	NM_003480	MFAP5	microfibrillar associated protein 5
chr1_-_36851484	6.516	NM_032017	STK40	serine/threonine kinase 40
chr5_+_59784004	6.468		PART1	prostate androgen-regulated transcript 1 (non-protein coding)
chr1_-_209824641	6.442	NM_001017402	LAMB3	laminin, beta 3
chr18_+_61442611	6.395	NM_003784	SERPINB7	serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr4_+_169753105	6.376	NM_001166110	PALLD	palladin, cytoskeletal associated protein
chr19_+_15160194	6.364	NM_012114	CASP14	caspase 14, apoptosis-related cysteine peptidase
chrX_+_149613719	6.281	NM_001177466 NM_005491	MAMLD1	mastermind-like domain containing 1
chr3_+_100238063	6.266		TMEM45A	transmembrane protein 45A
chr2_+_113875469	6.234	NM_000577 NM_173841 NM_173843	IL1RN	interleukin 1 receptor antagonist
chr11_-_108368918	6.180	NM_153705	KDELC2	KDEL (Lys-Asp-Glu-Leu) containing 2
chr11_-_118134986	6.161		MPZL2	myelin protein zero-like 2
chr10_+_24755440	6.129		KIAA1217	KIAA1217
chr11_-_118134868	6.125
chr16_-_75301950	6.064	NM_001170715	BCAR1	breast cancer anti-estrogen resistance 1
chr3_-_48632592	5.997	NM_000094	COL7A1	collagen, type VII, alpha 1
chr1_+_15256295	5.945	NM_001018001	KAZN	kazrin, periplakin interacting protein
chr19_-_55881740	5.871	NM_000641	IL11	interleukin 11
chr12_+_7023490	5.871	NM_001975	ENO2	enolase 2 (gamma, neuronal)
chr2_+_170366211	5.851	NM_006063	KBTBD10	kelch repeat and BTB (POZ) domain containing 10
chr20_-_1309809	5.740	NM_080489	SDCBP2	syndecan binding protein (syntenin) 2
chr12_-_133532847	5.684	NM_183238 NM_001164715	ZNF605	zinc finger protein 605
chr19_-_3969734	5.671	NM_001348	DAPK3	death-associated protein kinase 3
chr1_-_234743855	5.620
chr5_-_90610218	5.609		LOC100505994	uncharacterized LOC100505994
chr1_-_234743488	5.592		IRF2BP2	interferon regulatory factor 2 binding protein 2
chr19_-_51512803	5.562	NM_012315	KLK9	kallikrein-related peptidase 9
chr22_+_38598065	5.523		MAFF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chrX_+_115567820	5.520		SLC6A14	solute carrier family 6 (amino acid transporter), member 14
chr19_+_35521591	5.463	NM_001037 NM_199037	SCN1B	sodium channel, voltage-gated, type I, beta
chr11_-_118135197	5.428	NM_005797 NM_144765	MPZL2	myelin protein zero-like 2
chr10_+_24755459	5.422		KIAA1217	KIAA1217
chr1_+_35246789	5.401	NM_024009	GJB3	gap junction protein, beta 3, 31kDa
chr1_+_27719151	5.334	NM_005281	GPR3	G protein-coupled receptor 3
chr1_-_234743820	5.330
chr17_-_39743085	5.326	NM_000526	KRT14	keratin 14
chr5_+_53751430	5.299	NM_006308	HSPB3	heat shock 27kDa protein 3
chr8_+_86157732	5.298		CA13	carbonic anhydrase XIII
chr22_+_38597938	5.273	NM_001161572 NM_001161574 NM_012323	MAFF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr4_+_108745718	5.256	NM_001136258	SGMS2	sphingomyelin synthase 2
chr17_-_79881304	5.248	NM_032711	MAFG	v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)
chr13_+_76334796	5.176	NM_015842	LMO7	LIM domain 7
chr17_-_45928530	5.114		SP6	Sp6 transcription factor
chr6_-_13408368	5.104	NM_001242630	GFOD1	glucose-fructose oxidoreductase domain containing 1
chr2_+_87755059	4.931		LINC00152	long intergenic non-protein coding RNA 152
chr9_+_140172273	4.898	NM_017723	C9orf167	chromosome 9 open reading frame 167
chr21_+_30517897	4.829		C21orf7	chromosome 21 open reading frame 7
chr9_-_34662629	4.783	NM_006664	CCL27	chemokine (C-C motif) ligand 27
chr18_+_21452981	4.778	NM_000227 NM_001127718	LAMA3	laminin, alpha 3
chr12_+_78225068	4.744	NM_014903	NAV3	neuron navigator 3
chr6_+_106546736	4.731	NM_182907	PRDM1	PR domain containing 1, with ZNF domain
chr3_+_5021096	4.698	NM_003670	BHLHE40	basic helix-loop-helix family, member e40
chr8_+_86157693	4.696	NM_198584	CA13	carbonic anhydrase XIII
chr7_+_143078457	4.680		ZYX	zyxin
chr8_-_12973752	4.648	NM_001164271	DLC1	deleted in liver cancer 1
chr2_-_219858120	4.610	NM_005209 NM_057093 NM_057094	CRYBA2	crystallin, beta A2
chr1_-_223853400	4.596	NM_001143962	CAPN8	calpain 8
chr1_-_36851517	4.592		STK40	serine/threonine kinase 40
chr12_-_52886971	4.563	NM_005554	KRT6A	keratin 6A
chr4_-_77819001	4.563	NM_001029870	ANKRD56	ankyrin repeat domain 56
chr17_+_75446735	4.557		SEPT9	septin 9
chr10_-_90611675	4.549	NM_144590	ANKRD22	ankyrin repeat domain 22
chr17_-_36831156	4.510	NM_001130677	C17orf96	chromosome 17 open reading frame 96
chr7_+_143078444	4.509		ZYX	zyxin
chr5_+_177540465	4.503	NM_015111	N4BP3	NEDD4 binding protein 3
chr10_+_121410936	4.483		BAG3	BCL2-associated athanogene 3
chr8_+_86158004	4.471		CA13	carbonic anhydrase XIII
chr12_+_52445185	4.471	NM_002135 NM_173157	NR4A1	nuclear receptor subfamily 4, group A, member 1
chr7_+_143078395	4.469		ZYX	zyxin
chrX_-_19817854	4.463		SH3KBP1	SH3-domain kinase binding protein 1
chr9_+_138453599	4.453	NM_001018049 NM_002571	PAEP	progestagen-associated endometrial protein
chr7_+_143078399	4.422		ZYX	zyxin
chr9_+_33795558	4.413	NM_002771	PRSS3	protease, serine, 3
chr12_+_95676175	4.413		VEZT	vezatin, adherens junctions transmembrane protein
chr7_+_143078447	4.412		ZYX	zyxin
chr22_-_38714088	4.382	NM_001894	CSNK1E	casein kinase 1, epsilon
chr7_+_143078358	4.375	NM_001010972 NM_003461	ZYX	zyxin
chr10_+_121410751	4.316	NM_004281	BAG3	BCL2-associated athanogene 3
chr12_-_57328044	4.292	NM_148897	SDR9C7	short chain dehydrogenase/reductase family 9C, member 7
chr3_-_99833348	4.268	NM_001042459 NM_182909	FILIP1L	filamin A interacting protein 1-like
chr12_-_54813002	4.263		ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr3_-_87040246	4.224	NM_016206	VGLL3	vestigial like 3 (Drosophila)
chr10_+_121410891	4.222		BAG3	BCL2-associated athanogene 3
chr4_+_100737980	4.212	NM_014395	DAPP1	dual adaptor of phosphotyrosine and 3-phosphoinositides
chr18_+_61144143	4.192	NM_002639	SERPINB5	serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr12_-_54813010	4.175	NM_002205	ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr12_-_54812936	4.174		ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr11_-_102651321	4.154	NM_002425	MMP10	matrix metallopeptidase 10 (stromelysin 2)

Gene overrepresentation in process category:

Enrichment	P-value	GO Accession	GO Term
6.20	1.52e-12	GO:0008544	epidermis development
2.88	7.79e-10	GO:0009888	tissue development
12.16	2.97e-08	GO:0031424	keratinization
1.61	1.89e-06	GO:0032502	developmental process
1.64	3.04e-06	GO:0007275	multicellular organismal development
7.98	9.18e-06	GO:0030216	keratinocyte differentiation
1.70	1.06e-05	GO:0048731	system development
1.65	1.08e-05	GO:0048856	anatomical structure development
6.90	5.80e-05	GO:0009913	epidermal cell differentiation
1.83	1.09e-04	GO:0048513	organ development
1.41	2.12e-04	GO:0032501	multicellular organismal process
1.76	3.39e-04	GO:0030154	cell differentiation
1.73	5.37e-04	GO:0048869	cellular developmental process
3.82	3.59e-03	GO:0030855	epithelial cell differentiation
17.85	6.04e-03	GO:0031581	hemidesmosome assembly
9.82	7.01e-03	GO:0032963	collagen metabolic process
9.17	1.15e-02	GO:0044259	multicellular organismal macromolecule metabolic process
2.03	1.66e-02	GO:0009611	response to wounding
2.28	2.79e-02	GO:0042060	wound healing
1.95	3.29e-02	GO:0042127	regulation of cell proliferation
7.64	4.14e-02	GO:0044236	multicellular organismal metabolic process
9.43	4.39e-02	GO:0018149	peptide cross-linking

Gene overrepresentation in compartment category:

Enrichment	P-value	GO Accession	GO Term
16.83	2.11e-07	GO:0001533	cornified envelope
2.50	1.13e-04	GO:0030054	cell junction
3.81	1.52e-04	GO:0005911	cell-cell junction
3.57	4.90e-03	GO:0070161	anchoring junction
1.87	7.98e-03	GO:0044421	extracellular region part
12.27	8.17e-03	GO:0005605	basal lamina
2.70	9.25e-03	GO:0005578	proteinaceous extracellular matrix
1.67	1.22e-02	GO:0005856	cytoskeleton
2.50	1.28e-02	GO:0031012	extracellular matrix
5.05	1.54e-02	GO:0005604	basement membrane
3.83	3.30e-02	GO:0044420	extracellular matrix part

Gene overrepresentation in function category:

Enrichment	P-value	GO Accession	GO Term
5.53	3.71e-03	GO:0005200	structural constituent of cytoskeleton
3.37	4.12e-03	GO:0019901	protein kinase binding
2.18	1.02e-02	GO:0005198	structural molecule activity
2.88	3.07e-02	GO:0019900	kinase binding